Revolutionary Technology: A Leap Forward in Life Science
Exosome
What is exosome?
Exosomes are small extracellular vesicles, typically ranging from 30 to 150 nm in diameter, that are secreted by various types of cells. They play a critical role in cell-to-cell communication by carrying and transferring bioactive molecules such as proteins, lipids, and RNAs. Formed within multivesicular bodies (MVBs) and released when these MVBs fuse with the cell membrane.
Exosomes play roles in immune modulation, and due to their cargo reflecting the cell of origin, they are explored as non-invasive diagnostic tools for diseases like cancer. Additionally, exosomes have therapeutic potential in drug delivery and regenerative medicine, enhancing tissue repair by leveraging their natural signaling capabilities.
Nano-carrier Capability
High biocompatibility and tissue penetration
Therapeutic and Diagnostic Potential
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Plant exosome-like nanovesicles (PELNs)
Similar to mammalian exosomes, plant exosome-like nanovesicles (PELNs) are a group of nanoscale vesicles isolated from plants. These nanovesicles contain a broad range of membrane-bounded structures from distinct origins, including proteins, nucleic acid aggregates, and other chemical components. Compared with animal exosomes, PELNs have a larger particle size, ranging from 30 to 500 nm. Therefore, further purification is necessary to separate contaminants.
In human health, PELNs show promise as natural drug delivery systems, enhancing the stability and bioavailability of therapeutic agents. In recent years, research on the biological activity of PELNs has been favored by scholars. They also find applications in cosmetics for anti-aging and hydration, and in nutraceuticals for promoting overall health.
Grinding
Differential centrifugation
Resuspension in PBS
Certification and filtered
Pure PELNs
Pre PELNs
PELNs sendiment
Advantages over animal-derived exosomes
Lower
Metabolic Risk
Membranes of PELNs are enriched in glycerophospholipids, unlike animal-derived exosomes, which have membranes rich in cholesterol and sphingolipids that may contribute to metabolic syndrome when dysregulated.
Non-immunogenicity
PELNs are less likely to trigger immune responses compared to animal-derived exosomes, which can carry animal-specific antigens that might be recognized as foreign by the human immune system.
Therapeutic Potential
PELNs improve intercellular signaling, defense mechanisms, and interspecies communication. Their innate therapeutic properties can also be translated for human health.
Eco-friendly and Ethical
Plants can be cultivated in a lab with minimal tissue, making PELNs production more environmentally friendly than animal exosome. Additionally, plant-derived sources eliminate ethical concerns and regulatory complexities associated with animal products.